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For patients with severe deficiency or conditions such as pernicious anemia, our team may recommend an initial loading phase, which often involves administering 1000 mcg of B12 intramuscularly or subcutaneously daily or every other day for one to two weeks
These materials are not drugs, medications, dietary supplements, or medical products and have not been evaluated or approved by the U.S
If a persons B12 deficiency is due to diet, they may not require further shots or only require them once or twice per year
It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose
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For this reason, identifying strategies that reduce metabolic efficiency has long been of interest in experimental research
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